2018国际神经再生高峰论坛暨第十一届亚太神经再生论坛
Junfang Wu

Wu_Junfang.jpg

Junfang Wu, B.M., Ph.D.

副教授

麻醉科,休克,创伤和麻醉研究中心

马里兰大学医学院,美国


专家介绍

本实验室研究的总体目标是检查创伤性脊髓损伤(SCI)和脊髓损伤后经过药物以及基因疗法干预后的继发性损伤过程。具体而言,我们着重于以下几点:(1)阐明由脊髓损伤引起的脑部炎症的分子机制。这可能会发现有效的治疗方法来限制SCI后认知能力下降和抑郁倾向; 2)证明自噬 - 溶酶体途径和特异性microRNAsSCI后神经元损伤中的功能和机制,这可能为SCI开辟一条潜在的新的治疗途径,并为这些操作确定候选分子靶点;(3)确定影响SCI-PAIN的遗传和基因因素以及确定新的治疗方法以减少或消除SCI-PAIN,包括与激酶BtrkB)相关的BDNF受体原肌球蛋白的截短异构体trkB.T1; 4)探讨NOX2对实验性SCI和创伤性脑损伤(TBI)后疼痛反应行为和中枢疼痛调节的作用及机制。我的最终目的是了解SCI后功能恢复的细胞和分子机制,并制定潜在的治疗策略。


研究/临床关键词

脊髓损伤,脑损伤,炎症,自噬 - 溶酶体,神经性疼痛,NOX2,细胞循环途径,microRNA,自主功能,认知,抑郁,神经元,星形胶质细胞,小胶质细胞

Selected Recent Publications

Matyas JJ, O’Driscoll CM, Yu L, Coll-Miro M, Daugherty S, Renn CL, Faden AI, Dorsey SG, WuJ (2017) Truncated TrkB.T1-mediated astrocytes dysfunction contributes toimpaired motor function and neuropathic pain after spinal cord injury. J Neuroscience 37: 3956-3971.

Liu S, Sarkar C, Dinizo M, Faden AI, Koh EY, Lipinski MM, Wu J (2015). Disrupted autophagy afterspinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis 6:e1582.

Wu J, Zhao Z,Sabirzhanov B, Stoica BA, Kumar A, Luo T, Skovira J, Fade AI (2014). Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. Jf Neuroscience 34:10989-11006.

Wu J, Renn CL, Faden AI, Dorsey SG (2013) TrkB.T1 contributes to neuropathic pain following spinal cord Injury through regulation of cell cycle pathways. J Neuroscience 33:12447-12463.

Wu J, Yoo S, Wilcock D, Lytle LM, Leung PY, Colton CA, Wrathall JR (2010) Interaction of NG2+ glialprogenitors and microglia/macrophages from the injured spinal cord. Glia 58:410-422.